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Discovery of SAV-Specific, High-Affinity, Selective Antibody against KRAS G12D
KRAS is a key target in oncology with a number of clinically relevant single amino acid variants that lock it in a constitutively on confirmation and drive tumorigenesis. Yet KRAS is notoriously difficult to target.
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– Generating high-immunogenicity antigens with rational design
– Discovering high-affinity, specific, selective antibodies in a validated in vivo system
– Validating antibodies in vitro and in situ